Article
Glucose and lipid metabolism in young lean normotensive males with the G protein beta3 825T-allele.
European journal of medical research - 27 Mar 2003
Saller B, Nemesszeghy P, Mann K, Siffert W, Rosskopf D
Abstract excerpt
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity. Expression of Gbeta3s, the gene product of GNB3 associated with the GNB3 825T-allele, causes increased signal transduction which may contribute to pathogenetic mechanisms ultimately resulting in hypertension and obesity. Given the known...
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