Article
Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution.
Cell death and differentiation - 1 May 2003
Lacher M D, Siegenthaler A, Jäger R, Yan Xi, Hett S, Xuan L, Saurer S, Lareu R R, Dharmarajan A M, Friis R
Abstract excerpt
Using differential display, we isolated DDC-4, a secreted frizzled-related protein (sFRP), which is induced in the physiological apoptosis of hormonally regulated, reproductive tissues such as mammary gland, prostate, corpus luteum and uterus. The role of this gene in apoptosis was studied in animals overexpressing ectopic DDC-4/sFRP-4. Transgenic mice bearing the DDC-4/sFRP-4 cDNA under the control of the...
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