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Article

A modified digestion-circularization PCR (DC-PCR) approach to detect hypermutation-associated DNA double-strand breaks.

Annals of the New York Academy of Sciences - 1 Apr 2003

Dickerson Sarah K, Papavasiliou F Nina

Abstract excerpt

Hypermutation of immunoglobulin variable region genes occurs in B cells during an immune response, and is vital for the development of high-affinity antibodies. The molecular mechanism of the hypermutation reaction is unknown, but it seems to correlate with the generation of locus-specific, double-strand breaks. These DNA breaks have been measured by ligation-mediated polymerase chain reaction (LM-PCR), a...

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PMID: 12727632
DOI: 10.1111/j.1749-6632.2003.tb06041.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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