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Article

Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 2008

Lannergård Jonas, von Eiff Christof, Sander Gunnar, Cordes Tina, Seggewiss Jochen, Peters Georg, Proctor Richard A, Becker Karsten, Hughes Diarmaid

Abstract excerpt

Small-colony variants (SCVs) of Staphylococcus aureus are associated with persistent infections and may be selectively enriched during antibiotic therapy. Three pairs of clonally related S. aureus isolates were recovered from patients receiving systemic antibiotic therapy. Each pair consisted of an isolate with a normal phenotype and an isolate with an SCV phenotype. These SCVs were characterized by reduced...

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Identifiers

PMID: 18779359
DOI: 10.1128/AAC.00668-08
PMCID: PMC2573106

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