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A multivalent T-antigen-based vaccine for Group A Streptococcus

23 Feb 2021

Abstract excerpt

Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein component of the GAS pilus is the T-antigen, which multimerises to form the pilus shaft. There are currently no licenced vaccines against GAS infections and the T-antigen represents an attractive target for vaccination. We have generated a multivalent vaccine...

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PMID: 33623073
DOI: 10.1038/s41598-021-83673-4

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