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Article

Structural basis for variation in adenovirus affinity for the cellular coxsackievirus and adenovirus receptor.

The Journal of biological chemistry - 11 Jul 2003

Howitt Jason, Bewley Maria C, Graziano Vito, Flanagan John M, Freimuth Paul

Abstract excerpt

The majority of adenovirus serotypes can bind to the coxsackievirus and adenovirus receptor (CAR) on human cells despite only limited conservation of the amino acid residues that comprise the receptor-binding sites of these viruses. Using a fluorescence anisotropy-based assay, we determined that the recombinant knob domain of the fiber protein from adenovirus serotype (Ad) 2 binds the soluble, N-terminal domain...

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PMID: 12716886
DOI: 10.1074/jbc.M301492200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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