Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis.

Journal of virology - 1 Nov 2016

Ismail Ashrafali M, Lee Ji Sun, Dyer David W, Seto Donald, Rajaiya Jaya, Chodosh James

Abstract excerpt

Human adenoviruses (HAdVs) contain seven species (HAdV-A to -G), each associated with specific disease conditions. Among these, HAdV-D includes those viruses associated with epidemic keratoconjunctivitis (EKC), a severe ocular surface infection. The reasons for corneal tropism for some but not all HAdV-Ds are not known. The fiber protein is a major capsid protein; its C-terminal "knob" mediates binding with host...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Adenovirus Infections, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenoviruses, Human

Share to Capsid Proteins

Share to Cornea

Share to DNA, Viral

Share to Sequence Alignment

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 27512073
DOI: 10.1128/JVI.01010-16
PMCID: PMC5068513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis.PMID 27512073Read ↗

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species DSemantic proximity Read ↗

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactionsSemantic proximity Read ↗

Human adenovirus type 8: the major agent of epidemic keratoconjunctivitis (EKC).Semantic proximity Read ↗

Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic KeratoconjunctivitisSemantic proximity Read ↗

Phylogenetic Analysis and Structural Predictions of Human Adenovirus Penton Proteins as a Basis for Tissue-Specific Adenovirus Vector DesignSemantic proximity Read ↗

Identification of CD46 Binding Sites within the Adenovirus Serotype 35 Fiber KnobSemantic proximity Read ↗

Identification of a novel structural motif and overexpression of key transcripts elucidated in Adenovirus 10Semantic proximity Read ↗

An Arginine Switch in the Species B Adenovirus Knob Determines High-Affinity Engagement of Cellular Receptor CD46Semantic proximity Read ↗

Human adenovirus binding to host cell receptors: a structural viewSemantic proximity Read ↗

The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanismSemantic proximity Read ↗

Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapySemantic proximity Read ↗

Structural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CARSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.