Article
Regulatory effect of SOCS on NF-kappaB activity in murine monocytes/macrophages.
DNA and cell biology - 1 Feb 2003
Park Sun-Hee, Kim Kyoung-Eun, Hwang Ha-Young, Kim Tae Yoon
Abstract excerpt
The suppressor of cytokine signaling (SOCS) group of proteins has been implicated in regulation of various cytokine signaling and in a negative crosstalk between distinct signaling pathways. Interleukin-10 (IL-10) and LPS were known to induce expression of SOCS-3 in neutrophils and monocytes/macrophages. IL-10 was also reported to inhibit a proinflammatory signal-induced NF-kappaB activation in monocytes and...
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