Article
Reduced fitness of HIV-1 resistant to CXCR4 antagonists.
Antiviral therapy - 1 Feb 2003
Armand-Ugón Mercedes, Quiñones-Mateu Miguel E, Gutiérez Arantxa, Barretina Jordi, Blanco Julià, Schols Dominique, De Clercq Erik, Clotet Bonaventura, Esté José A
Abstract excerpt
HIV-1 strains with a syncytium-inducing phenotype that use CXCR4 (X4 strains) have been associated with faster disease progression and AIDS. Antiviral agents designed to block CXCR4 may prevent the emergence of X4 HIV strains but resistant strains that maintain the X4 phenotype can be raised by sequential passage in cell cultures. We have demonstrated that a laboratory adapted strain (NL4-3) and a cloned clinical...
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