Article
[Alterations of p16 gene in transformed BEP2D cells induced by NNK].
Wei sheng yan jiu = Journal of hygiene research - 30 May 1999
Sun H, Gong Y, Wang Q, Chen J
Abstract excerpt
Silver-staining PCR-SSCP method was used to detect the alterations of p16 gene in the transformed BEP2D cells induced by NNK. Compared with control cells, the abnormal shifting of the single-stranded DNA(ssDNA) in E1. beta but not p16 Exon 1-3 was identified in transformed BEP2D cells. The results suggested that the mutation and/or deletion in p16 gene might be one cause of NNK-unduced carcinogenesis in human...
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