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Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

15 Jun 1999

Abstract excerpt

BACKGROUND: We previously reported that FTY720, a metabolite from Isaria sinclairii, induced some cancer cells to undergo apoptosis, and that FTY720-induced apoptosis was not related to Fas-antigens. In this study we investigated whether FTY720 was able to induce apoptosis in an androgen-independent prostate cancer cell line, DU145, which is not only resistant to androgen-withdrawal-induced apoptosis but also...

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PMID: 10344723
DOI: 10.1002/(sici)1097-0045(19990615)40:1<50::aid-pros6>3.0.co;2-n

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