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Article

Mitochondrial gene segregation in mammals: is the bottleneck always narrow?

Human genetics - 1 Jan 2000

Howell N, Halvorson S, Kubacka I, McCullough D A, Bindoff L A, Turnbull D M

Abstract excerpt

The segregation of a heteroplasmic silent polymorphism in the mitochondrial ND6 gene has been followed in a human maternal lineage comprising eight individuals and spanning three generations. Heteroplasmy persisted in all eight maternally related family members. More importantly, the frequencies of the two alleles showed relatively little variation among individuals or between generations. In contrast to the...

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PMID: 1427765
DOI: 10.1007/BF00210753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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