Article
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
Human genetics - 1 Jan 2000
Howell N, Halvorson S, Kubacka I, McCullough D A, Bindoff L A, Turnbull D M
Abstract excerpt
The segregation of a heteroplasmic silent polymorphism in the mitochondrial ND6 gene has been followed in a human maternal lineage comprising eight individuals and spanning three generations. Heteroplasmy persisted in all eight maternally related family members. More importantly, the frequencies...
Topics
- Alleles
- Base Sequence
- DNA, Mitochondrial
- Female
- Humans
- Male
- Mathematics
- Molecular Sequence Data
- Oligonucleotide Probes
- Optic Atrophies, Hereditary
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic