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Article

Global and non‐random CpG‐island methylation in gastric carcinoma associated with Epstein‐Barr virus

1 Jan 2003

Abstract excerpt

DNA hypermethylation may play a primary role in the genesis of Epstein-Barr virus (EBV)-associated gastric carcinoma (GC) (EBVaGC). Methylation-specific PCR targeting CpG-islands demonstrated markedly increased methylation of specific genes, such as p14, p15 and p16 genes, in EBVaGC in vivo. A high frequency of methylation was observed in an EBVaGC strain of severe combined immunodeficiency mice, and the...

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PMID: 12708478
DOI: 10.1111/j.1349-7006.2003.tb01355.x

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