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Article

Epigenetic silencing of tumor suppressor genes during in vitro Epstein–Barr virus infection

31 Aug 2015

Abstract excerpt

DNA-methylation at CpG islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. Hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (TSG) silencing mechanisms, widely contribute to the development of multiple human cancers. Furthermore, oncogenic viruses, including Epstein-Barr virus (EBV)-associated human cancers, were also shown...

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PMID: 26324942
DOI: 10.1073/pnas.1503806112

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