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The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer

25 Jul 2017

Abstract excerpt

The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma (EBVaGC), all tumor cells harbor the clonal EBV genome. The expression of latent EBV genes is strictly regulated through the methylation of EBV DNA. The methylation of viral DNA regulates the type of EBV latency, and methylation of the tumor suppressor genes is a key...

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PMID: 28757548
DOI: 10.3390/ijms18081606

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