Article
Lack of Fas (APO-1/CD95) gene structural alterations or transcript variant ratio changes in breast cancer.
Cancer letters - 8 May 2003
Puiu Liliana, Petrakou Eftichia, Apostolidou Anastasia, Athanassiadou Aglaia, Psiouri Lambrini, Papachatzopoulou Adamantia, Gorgoulis Vassilis G, Kotsinas Athanassios, Tzoracoeleftherakis Evangelos, Maniatis George M, Voutsinas Gerassimos
Abstract excerpt
Fas (APO-1/CD95) is a transmembrane receptor protein involved in cell death signaling. Fas receptor and ligand are both expressed in breast cancer cells, however these cells are resistant to apoptosis. Fas gene mutations were detected in hematological and solid tumors, while overexpression of a soluble Fas isoform in serum was related to cancer stage and prognosis. In this work, direct sequencing of exons 6 and 9...
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