Article
When the lymphocyte loses its clothes.
Immunity - 1 Apr 2003
Nekrep Nada, Fontes Joseph D, Geyer Matthias, Peterlin B Matija
Abstract excerpt
The type II bare lymphocyte syndrome (BLS) or major histocompatibility complex class II (MHCII) deficiency is a severe combined immunodeficiency (SCID) that is characterized by the absence of constitutive and inducible expression of MHCII determinants on immune cells. Four complementation groups of BLS have been defined, and they result from mutations in DNA-bound activators and the coactivator for MHCII...
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