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Article

The Bare Lymphocyte Syndrome and the Regulation of MHC Expression

1 Apr 2001

Abstract excerpt

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the absence of major histocompatibility complex class II (MHCII) expression. Considering the central role of MHCII molecules in the development and activation of CD4(+) T cells, it is not surprising that the immune system of the patients is severely impaired. BLS is the prototype of a "disease of gene regulation." The affected...

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Identifiers

PMID: 11244040
DOI: 10.1146/annurev.immunol.19.1.331

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Related research

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The Bare Lymphocyte Syndrome and the Regulation of MHC ExpressionPMID 11244040Read ↗

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