Article
Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.
The Journal of experimental medicine - 1 Jun 1994
Kovats S, Drover S, Marshall W H, Freed D, Whiteley P E, Nepom G T, Blum J S
Abstract excerpt
The human immunodeficiency, type II bare lymphocyte syndrome (BLS), has been attributed to a defect in the transcription of class II histocompatibility genes. Immunocompetence, as assessed by functional exogenous antigen presentation, was not restored in immortalized B cells, derived from a BLS p...
Topics
- Alleles
- Amino Acid Sequence
- Cell Fusion
- Cell Line
- Clone Cells
- Gene Expression
- Genes
- Genes, MHC Class II
- Genetic Complementation Test
- HLA-D Antigens
- Humans
- Immunologic Deficiency Syndromes
- Molecular Sequence Data
- Oligopeptides
- T-Lymphocytes