Article
Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.
The Journal of experimental medicine - 1 Jun 1994
Kovats S, Drover S, Marshall W H, Freed D, Whiteley P E, Nepom G T, Blum J S
Abstract excerpt
The human immunodeficiency, type II bare lymphocyte syndrome (BLS), has been attributed to a defect in the transcription of class II histocompatibility genes. Immunocompetence, as assessed by functional exogenous antigen presentation, was not restored in immortalized B cells, derived from a BLS patient, after transfection with HLA-DR class II structural genes. Incubation of protein antigens, as well as infectious...
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