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Heterozygosity for the BLM(Ash) mutation and cancer risk.

Cancer research - 15 Apr 2003

Cleary Sean P, Zhang William, Di Nicola Nando, Aronson Melyssa, Aube Jennifer, Steinman Amanda, Haddad Riad, Redston Mark, Gallinger Steven, Narod Steven A, Gryfe Robert

Abstract excerpt

Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individuals, including 497 individuals with colorectal cancer, 125 with adenomatous polyps, 767 with...

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Identifiers

PMID: 12702560

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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