Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The spectrum of patched mutations in a collection of Australian basal cell carcinomas.

Human mutation - 1 Jan 2000

Evans T, Boonchai W, Shanley S, Smyth I, Gillies S, Georgas K, Wainwright B, Chenevix-Trench G, Wicking C

Abstract excerpt

Inactivating mutations in the human patched (PTCH) gene have been identified in both familial and sporadic basal cell carcinomas (BCCs). In some tumors mutations have been detected in both alleles thereby supporting the role of PTCH as a tumor suppressor gene. We have analyzed 22/23 coding exons of PTCH for mutations in 44 sporadic BCCs, and detected 10 novel mutations in nine tumors. In two of the mutant tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia
Share to Carcinoma, Basal Cell
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Receptors, Cell Surface

Share to Skin Neoplasms

Source

Identifiers

PMID: 10874304
DOI: 10.1002/1098-1004(200007)16:1<43::AID-HUMU8>3.0.CO;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The spectrum of patched mutations in a collection of Australian basal cell carcinomas.PMID 10874304Read ↗

UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients.Semantic proximity Read ↗

High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum.Semantic proximity Read ↗

UV fingerprints predominate in the PTCH mutation spectra of basal cell carcinomas independent of clinical phenotype.Semantic proximity Read ↗

Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms.Semantic proximity Read ↗

UV mutation signature in tumor suppressor genes involved in skin carcinogenesis in xeroderma pigmentosum patients.Semantic proximity Read ↗

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.Semantic proximity Read ↗

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.Semantic proximity Read ↗

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.Semantic proximity Read ↗

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.