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Article

Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis.

British journal of pharmacology - 1 Mar 2003

Raiteri Luca, Paolucci Egle, Prisco Simona, Raiteri Maurizio, Bonanno Giambattista

Abstract excerpt

The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice. Mice expressing mutated SOD1 were killed at the advanced phase of the pathology, when they showed signs of ingestion disability,...

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Identifiers

PMID: 12684256
DOI: 10.1038/sj.bjp.0705142
PMCID: PMC1573752

Genes

SOD1

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