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Article

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

Molecular and cellular biology - 1 May 2003

Chan Perry M, Ilangumaran Subburaj, La Rose Jose, Chakrabartty Avijit, Rottapel Robert

Abstract excerpt

Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive ac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12697809
DOI: 10.1128/MCB.23.9.3067-3078.2003
PMCID: PMC153186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12697809-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.PMID 12697809Read ↗

Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation.Semantic proximity Read ↗

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Signal transduction by several KIT juxtamembrane domain mutations.Semantic proximity Read ↗

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Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.Semantic proximity Read ↗

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Semantic proximity Read ↗

Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.Semantic proximity Read ↗

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