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Article

Rescue of MODY-1 by agonist ligands of hepatocyte nuclear factor-4alpha.

The Journal of biological chemistry - 20 Jun 2003

Hertz Rachel, Ben-Haim Nadav, Petrescu Anca D, Kalderon Bella, Berman Inna, Eldad Naama, Schroeder Friedhelm, Bar-Tana Jacob

Abstract excerpt

Missense mutations of the ligand binding domain of hepatocyte nuclear factor (HNF)-4alpha result in maturity onset diabetes of the young (MODY)-1. We show here that MODY-1 as well as Gln-185 missense mutants of the ligand binding domain of HNF-4alpha fail to transactivate transcription of HNF-4alpha-responsive genes. Defective transactivation by these mutants is accounted for by their reduced binding affinities...

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Identifiers

PMID: 12697772
DOI: 10.1074/jbc.M212138200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Rescue of MODY-1 by agonist ligands of hepatocyte nuclear factor-4alpha.PMID 12697772Read ↗

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