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Bordetella pertussisProtein Pertactin Induces Type‐Specific Antibodies: One Possible Explanation for the Emergence of Antigenic Variants?

15 Apr 2003

Abstract excerpt

Divergence has been found between Bordetella pertussis vaccine strains and circulating strains. Polymorphism in pertactin (Prn) is essentially limited to region 1, which is made up of repeats. Today, the 3 most prevalent Prn variants are Prn1-3. Vaccine strains produce Prn1, whereas Prn2 is the predominant type found in circulating strains. We investigated how variation in region 1 affects the production of human...

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PMID: 12695998
DOI: 10.1086/368412

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