Epithelial carcinogenesis: challenging monoclonality.

doi:10.1002/path.1349

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Article

Epithelial carcinogenesis: challenging monoclonality.

The Journal of pathology - 1 May 2003

Going James J

Abstract excerpt

How carcinomas begin remains unclear, but experimental data do not entirely exclude the participation of more than one clone of neoplastic cells, even in relatively advanced epithelial tumour growth. Microdissection and new PCR clonality assays exploiting X-linked polymorphisms, some of which (including XIST) are expressed in RNA, create investigational opportunities complementary to other molecular analyses, but...

Topics

Breast Neoplasms
Carcinoma
Cell Transformation, Neoplastic
Chromosomes, Human, X
DNA, Neoplasm
Dosage Compensation, Genetic
Female
Humans
Models, Biological
Mosaicism
Mutation
Neoplasms
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 12692834
DOI: 10.1002/path.1349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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