Article
Patterns of X chromosome inactivation in sporadic basal cell carcinomas: evidence for clonality.
Journal of the American Academy of Dermatology - 1 Jan 1998
Walsh D S, Peacocke M, Harrington A, James W D, Tsou H C
Abstract excerpt
BACKGROUND: Some basal cell carcinomas (BCCs) contain genetic mutations, suggesting that the lesion is composed of a monoclonal population of cells. Clonality, a distinguishing feature of neoplasia, can be inferred by referencing clonal markers such as the pattern of X chromosome inactivation. The X-linked human androgen receptor gene (HUMARA; GenBank) contains a polymorphic DNA marker that reliably illustrates...
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