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The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2003

Kadlubar Fred F, Berkowitz Gertrud S, Delongchamp Robert R, Wang Charles, Green Bridgett L, Tang George, Lamba Jatinder, Schuetz Erin, Wolff Mary S

Abstract excerpt

Breast development, one of the first signs of puberty, is closely associated with age at menarche; and early menarche is in turn a well-established risk factor for female breast cancer. We examined the relationships between the onset of puberty and gene variants for certain enzymes that regulate hormone metabolism among 137 healthy nine-year-old girls from two pediatric clinics. High-activity CYP17 alleles,...

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PMID: 12692107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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