Article
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
The Journal of biological chemistry - 20 Jun 2003
Lund Erik G, Xie Chonglun, Kotti Tiina, Turley Stephen D, Dietschy John M, Russell David W
Abstract excerpt
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted bile acids. The synthesis of bile acids is limited to the liver, but several enzymes in the bile acid biosynthetic pathway are expressed in extra-hepatic tissues and there also may contribute to cholesterol turnover. An example of the latter type of enzyme is cholesterol 24-hydroxylase,...
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