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The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols

2 May 2006

Abstract excerpt

Mice with a targeted mutation of 3beta-hydroxysterol Delta(7)-reductase (Dhcr7) that cannot convert 7-dehydrocholesterol to cholesterol were used to identify the origin of fetal sterols. Because their heterozygous mothers synthesize cholesterol normally, virtually all sterols found in a Dhcr7 knockout fetus having a Delta(7) or a Delta(8) double bond must have been synthesized by the fetus itself but any...

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PMID: 16651660
DOI: 10.1194/jlr.m600141-jlr200

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