Article
The Sr1 gene that controls diversity of the anti-inulin antibody response maps to mouse chromosome 14.
Immunogenetics - 1 May 2003
Jones Tiffany Linda, Riblet Roy, Stein Kathryn E
Abstract excerpt
Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown by isoelectric focusing analysis. In contrast, the anti-In antibody response of (BALB/cxC57BL/6)F1 mice is significantly more heterogeneous. We performed a backcross...
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