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Article

Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy

1 Oct 2008

Abstract excerpt

Since it is important to lower the death threshold in tumor cells and to enhance response to genotoxic damage, the mechanisms of bromodeoxyuridine (BrdU)-mediated radiosensitization were now examined in human C8161 melanoma. This revealed that anti-apoptotic Bcl-2, and cell cycle controlling hyperphosphorylated Rb and cyclin A were downregulated by BrdU, even without irradiation. BrdU pretreatment and subsequent...

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PMID: 18769121
DOI: 10.4161/cbt.7.10.6540

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