Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor.

Seminars in radiation oncology - 1 Apr 1999

King T C, Estalilla O C, Safran H

Abstract excerpt

Molecular genetic alterations that disturb cell cycle regulation in tumor cells can affect their response to chemotherapeutic agents and radiation. Many genes that regulate the critical cell cycle checkpoint at G1S are altered in human tumors. These genetic changes can result in uncontrolled cellular proliferation, genetic instability, and altered response to radiation and chemotherapy. The p53 tumor suppressor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Combined Modality Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, cdc

Share to Genes, p16

Share to Paclitaxel

Share to Pancreatic Neoplasms

Share to Radiation-Sensitizing Agents

Share to Stomach Neoplasms

Source

Identifiers

PMID: 10210535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor.PMID 10210535Read ↗

p16INK4a Modulates p53 in Primary Human Mammary Epithelial CellsSemantic proximity Read ↗

Weekly paclitaxel as a radiation sensitizer for locally advanced gastric and pancreatic cancers: the Brown University Oncology Group experience.Semantic proximity Read ↗

Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines.Semantic proximity Read ↗

Molecular effects of paclitaxel: Myths and reality (a critical review)Semantic proximity Read ↗

p16(MTS-1/CDKN2/INK4a) in Cancer ProgressionSemantic proximity Read ↗

Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.Semantic proximity Read ↗

Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism.Semantic proximity Read ↗

Molecular effects of taxol and caffeine on pancreatic cancer cells.Semantic proximity Read ↗

Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.Semantic proximity Read ↗

p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma.Semantic proximity Read ↗

p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck TumorsSemantic proximity Read ↗

p53-independent apoptosis induced by paclitaxel through an indirect mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.