Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.

Abstract excerpt

We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dinucleotide Repeats
• Share to Drosophila
• Share to Evolution, Molecular