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Article

Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.

Journal of cell science - 15 May 2003

Ono Kanako, Parast Mana, Alberico Christine, Benian Guy M, Ono Shoichiro

Abstract excerpt

Actin depolymerizing factor (ADF)/cofilin is an essential enhancer of actin turnover. Multicellular organisms express multiple ADF/cofilin isoforms in different patterns of tissue distribution. However, the functional significance of different ADF/cofilin isoforms is not understood. The Caenorhabditis elegans unc-60 gene generates two ADF/cofilins, UNC-60A and UNC-60B, by alternative splicing. These two...

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PMID: 12679387
DOI: 10.1242/jcs.00421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.PMID 12679387Read ↗

UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.Semantic proximity Read ↗

Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.Semantic proximity Read ↗

Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.Semantic proximity Read ↗

The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans.Semantic proximity Read ↗

The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans.Semantic proximity Read ↗

Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.Semantic proximity Read ↗

CAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.Semantic proximity Read ↗

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Form and function of actin impacts actin health and agingSemantic proximity Read ↗

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