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Article

Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.

The Journal of cell biology - 18 Mar 2002

Ono Shoichiro, Ono Kanako

Abstract excerpt

Tropomyosin binds to actin filaments and is implicated in stabilization of actin cytoskeleton. We examined biochemical and cell biological properties of Caenorhabditis elegans tropomyosin (CeTM) and obtained evidence that CeTM is antagonistic to ADF/cofilin-dependent actin filament dynamics. We purified CeTM, actin, and UNC-60B (a muscle-specific ADF/cofilin isoform), all of which are derived from C. elegans, and...

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Identifiers

PMID: 11901171
DOI: 10.1083/jcb.200110013
PMCID: PMC2173459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.PMID 11901171Read ↗

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Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.Semantic proximity Read ↗

Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.Semantic proximity Read ↗

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