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Article

[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jan 2003

Gu Long-jun, Ye Qi-dong, Liang Ai-bin, Zhao Jin-cai, Xue Hui-liang, Tang Yao-nian, Chen Jing, Ye Yu-chun

Abstract excerpt

OBJECTIVE: To evaluate the activity and genotype of thiopurine methyltransferase (TPMT) and the concentration of thioguanine nucleotides (TGNs) as parameters for individualizing mercaptopurine (6-MP) therapy. METHODS: Erythrocyte TPMT activity was measured by means of radiochemical assay. Sequence specific primer (SSP) PCR and restriction fragment length polymorphism (RFLP) were used to determine the mutations in...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12679004

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].PMID 12679004Read ↗

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