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[Thiopurine S-methyltransferase gene sequence analysis of ALL children severely intolerant to 6-mercaptopurine].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2012

Ma Xiao-Li, Li Wei-Jing, Zheng Jie, Wang Bin, Jin Mei, Zhang Da-Wei, Li Zhi-Gang, Zhang Yu-Xiang

Abstract excerpt

This study was aimed to analyze the thiopurine S-methyltransferase (TPMT) gene sequence in acute lymphoblastic leukemia (ALL) children severely intolerant to 6-mercaptopurine (6-MP) and to investigate the causes resulting in tolerance difference to 6-MP in ALL children so as to provide evidence for safe and rational use of 6-MP. The adverse reactions of drug was evaluated in ALL children treated with BCH-2003-ALL...

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Identifiers

PMID: 22931646

Genes

TPMT

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[Thiopurine S-methyltransferase gene sequence analysis of ALL children severely intolerant to 6-mercaptopurine].PMID 22931646Read ↗

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[Studies on the mutation and polymorphism of the TPMT gene in Chinese children with acute leukemia].Semantic proximity Read ↗

Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity.Semantic proximity Read ↗

Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.Semantic proximity Read ↗

Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.Semantic proximity Read ↗

Influence of thiopurine methyltransferase gene polymorphism on Egyptian children with acute lymphoblastic leukaemia.Semantic proximity Read ↗

The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

[Relationships between thiopurine methyltransferase gene polymorphisms and its enzymatic activity].Semantic proximity Read ↗

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