Article
Pituitary adenylyl cyclase-activating polypeptide receptor re-sensitization induces plastic changes in the dopaminergic phenotype in the mature avian retina.
Journal of neurochemistry - 1 Mar 2013
Fleming Renata L, Silveira Mariana S, Santos Luís E, Henze Isabela P, Gardino Patrícia F, de Mello Maria Christina F, de Mello Fernando G
Abstract excerpt
Pituitary Adenylyl Cyclase-Activating Polypeptide (PACAP) is a neuroactive peptide present in the avian retina where it activates adenylyl cyclase (AC) since early in development via PACAP receptors. The synthesis of cAMP in response to PACAP is observed since embryonic day 8/9 (E8/9). After E12, signaling via PACAP receptors desensitizes, reaching very low levels in the mature tissue. We show here that chronic...
Topics
- Animals
- Blotting, Western
- Chickens
- Cyclic AMP
- Dopamine
- Immunohistochemistry
- Neuronal Plasticity
- Phenotype
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
- Retina
- Reverse Transcriptase Polymerase Chain Reaction