Article
Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer.
Human mutation - 1 May 2003
Bernstein Jonine L, Teraoka Sharon, Haile Robert W, Børresen-Dale Anne-Lise, Rosenstein Barry S, Gatti Richard A, Diep Anh T, Jansen Laila, Atencio David P, Olsen Jørgen H, Bernstein Leslie, Teitelbaum Susan L, Thompson W Douglas, Concannon Patrick
Abstract excerpt
Epidemiologic studies of breast and other cancers are increasingly turning toward large, multi-center designs in order to obtain adequate power to detect low-penetrance susceptibility alleles. The size of such studies often makes it necessary to distribute the genetic screening efforts to multiple sites. Careful standardization of screening methodology and quality control across sites is required for such...
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