Article
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.
Human pathology - 1 Mar 2003
Wehrli Bret Michael, Huang Wendong, De Crombrugghe Benoit, Ayala Alberto G, Czerniak Bogdan
Abstract excerpt
Over the last decade, a number of "master regulator" genes that control distinct pathways of mesenchymal differentiation have been discovered. These genes are expressed early during embryogenesis and initiate a cascade of gene expression responsible for specific cell lineage commitment. Thus, identification of their products may allow the classification of seemingly primitive, morphologically uncommitted tumors...
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