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Molecular profiling of human chondrosarcomas for matrix production and cancer markers

16 May 2002

Abstract excerpt

Chondrosarcoma is the second most common malignant bone tumor, characterized by production of abundant extracellular matrix resembling hyaline cartilage. To better understand the molecular pathogenesis of chondrosarcoma, we analyzed 12 chondrosarcomas for their production of connective tissue components and SOX9, a key regulator of normal chondrocyte differentiation. Furthermore, 10 chondrosarcoma samples were...

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PMID: 12115562
DOI: 10.1002/ijc.10457

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