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Article

Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.

PloS one - 1 Jan 2014

Hettwer Stefan, Lin Shuo, Kucsera Stefan, Haubitz Monika, Oliveri Filippo, Fariello Ruggero G, Ruegg Markus A, Vrijbloed Jan W

Abstract excerpt

Treatment of neuromuscular diseases is still an unsolved problem. Evidence over the last years strongly indicates the involvement of malformation and dysfunction of neuromuscular junctions in the development of such medical conditions. Stabilization of NMJs thus seems to be a promising approach to attenuate the disease progression of muscle wasting diseases. An important pathway for the formation and maintenance...

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Identifiers

PMID: 24520420
DOI: 10.1371/journal.pone.0088739
PMCID: PMC3919806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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