Article
Cell-specific proteins regulate viral RNA translation and virus-induced disease.
The EMBO journal - 3 Dec 2001
Pilipenko E V, Viktorova E G, Guest S T, Agol V I, Roos R P
Abstract excerpt
Translation initiation of the picornavirus genome is regulated by an internal ribosome entry site (IRES). The IRES of a neurovirulent picornavirus, the GDVII strain of Theiler's murine encephalomyelitis virus, requires polypyrimidine tract-binding protein (PTB) for its function. Although neural cells are deficient in PTB, they express a neural-specific homologue of PTB (nPTB). We now show that nPTB and PTB bind...
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