Article
Thyroid-specific transcription factors control Hex promoter activity.
Nucleic acids research - 1 Apr 2003
Puppin Cinzia, D'Elia Angela V, Pellizzari Lucia, Russo Diego, Arturi Franco, Presta Ivan, Filetti Sebastiano, Bogue Clifford W, Denson Lee A, Damante Giuseppe
Abstract excerpt
The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue- specific genes. In this study the regulation of Hex promoter activity was investigated. Using co- transfection experiments, we demonstrated that the transcriptional activity of the Hex gene promoter in rat thyroid FRTL-5 cells is approximately 10-fold greater...
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