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Article

Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa.

Infection and immunity - 1 Apr 2003

Loughlin Michael F, Barnard Faye M, Jenkins David, Sharples Gary J, Jenks Peter J

Abstract excerpt

Homologous recombination contributes to the extraordinary genetic diversity of Helicobacter pylori and may be critical for surface antigen expression and adaptation to environmental challenges within the stomach. We generated isogenic, nonpolar H. pylori ruvC mutants to investigate the function of RuvC, a Holliday junction endonuclease that resolves recombinant joints into nicked duplex products. Inactivation of...

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Identifiers

PMID: 12654822
DOI: 10.1128/IAI.71.4.2022-2031.2003
PMCID: PMC152077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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