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Article

Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1.

Experimental lung research - 1 Jan 2000

Shiomi Takayuki, Okada Yasunori, Foronjy Robert, Schiltz John, Jaenish Rudolph, Krane Steve, D'Armiento Jeanine

Abstract excerpt

Disruption of the extracellular matrix is believed to play an important role in the pathogenesis of emphysema. Prior studies have demonstrated that transgenic mice expressing the human tissue collagenase, matrix metalloproteinase 1 (MMP-1), develop emphysema. MMP-1 is a protease with substrate specificity for fibrillar collagen. Type I and III collagens, which are the most abundant proteins within the lungs, are...

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PMID: 12652812
DOI: 10.1080/01902140303761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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