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Article

Cathepsin gene expression in abdominal subcutaneous adipose tissue of obese/overweight humans.

Adipocyte - 1 Jan 2020

Xu Qing, Mariman Edwin C M, Goossens Gijs H, Blaak Ellen E, Jocken Johan W E

Abstract excerpt

Cathepsin L1 (CTSL1) and B (CTSB) are lysosomal proteases, of which the expression and activity are impaired in adipose tissue (AT) of obese rodents, indicating AT lysosomal dysfunction. Here we assess the relation between abdominal subcutaneous AT (SCAT) CTSL1 and CTSB gene expression (qRT-PCR), body composition and tissue-specific insulin resistance in 77 overweight/obese (BMI: 225.6-38.6 kg/m2) well phenotyped...

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Source

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Identifiers

PMID: 32486882
DOI: 10.1080/21623945.2020.1775035
PMCID: PMC7469552

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