Article

Cathepsin B-Mediated Dysregulation of Autophagy Impairs Macrophage Function and Delays Healing in Diabetic Foot Ulcers

2026-08-24

Abstract excerpt

<title>Abstract</title> <p>Diabetic foot ulcers (DFU) represent one of the most prevalent and debilitating complications of diabetes. In this study, we investigated the role of cathepsin B (CTSB) in regulating macrophage autophagy and its contribution to DFU pathogenesis under hyperglycaemic conditions. By integrating bulk RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) datasets, we identified...

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Literature Corpus work: 46aca72d-4e75-56c1-a10c-6676b7f4052f
DOI: 10.21203/rs.3.rs-10615660/v1

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Cathepsin B-Mediated Dysregulation of Autophagy Impairs Macrophage Function and Delays Healing in Diabetic Foot UlcersDOI 10.21203/rs.3.rs-10615660/v1Read

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