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Article

Tpit determines alternate fates during pituitary cell differentiation.

Genes & development - 15 Mar 2003

Pulichino Anne-Marie, Vallette-Kasic Sophie, Tsai Judy Peih-Ying, Couture Catherine, Gauthier Yves, Drouin Jacques

Abstract excerpt

The T-box transcription factor Tpit was identified as a cell-specific factor for expression of the pituitary proopiomelanocortin (POMC) gene. Expression of this factor is exclusively restricted to the pituitary POMC-expressing lineages, the corticotrophs and melanotrophs. We have now determined the role of this factor in pituitary cell differentiation. Tpit is a positive regulator for late POMC cell...

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Source

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Identifiers

PMID: 12651892
DOI: 10.1101/gad.1065703
PMCID: PMC196016

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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